(Title image: Ultrasound-encoded wavefront used for optical resolution imaging with diffuse light. See publications)
We are a group of neuroscientists, engineers, biologists and physicists who develop and apply new optical techniques to study brain circuits at depths that have long been unreachable. The lab is part of the Einstein Center for Neurosciences and is located on the Charité / Humboldt University campus in the centre of Berlin.
Benjamin Judkewitz, professor in Bioimaging and Neurophotonics.
2010 - 2014: Sir Henry Wellcome Postdoctoral fellow at the California Institute of Technology, departments of Electrical Engineering and Bioengineering
2006 - 2010: PhD in Neuroscience and Physiology at University College London.
2000- 2005: Biology undergraduate training in Heidelberg, Berkeley and at the Max Planck Institute for Medical Research.
If all our bodies were as transparent as these jellyfish, the implications for biomedical science would be tremendous. Biologists could directly look at deep tissues to study their function and doctors could diagnose diseases such as cancer by direct observation.
Yet, when light propagates through most biological tissues, refractive index inhomogeneities cause diffuse scattering that increases with depth. This poses a major challenge to optical techniques, fundamentally limiting their biomedical usefulness to thin sections or cultured cells in vitro and superficial layers of tissue in vivo. As a result, despite many breakthroughs enabled by advances in optical imaging and optogenetics, these techniques are still severely handicapped by scattering.
The goal of our research is to address this challenge by developing new optical techniques based on wavefront engineering and optical time reversal. These approaches, in combination with calcium imaging and electrophysiology, will enable us to study circuits of the brain that have thus far been inaccessible to noninvasive optical methods.